SLAY THE SPIRE / SILENT

Catalyst

Multiplies existing Poison, making a committed Poison engine lethal quickly.

QUICK REFERENCESlay the Spire 1Reviewed 2026-10-28Reference / noindex
Original schematic Volpedia category artwork
OVERVIEW

What is Catalyst?

Multiplies existing Poison, making a committed Poison engine lethal quickly.

This reference covers gameplay decisions in the original Slay the Spire. Character-specific options and relic synergy can change how useful an item is, so consider your current deck, health, upcoming enemy and available resources before applying a strategy.

PRACTICAL STRATEGY

When and how to use it

Wait until enough Poison is applied or draw enables the combo within a safe turn.

COMMON MISTAKES

What to avoid

Casting it before Poison is present loses nearly all its value.

CONTINUE ON VOLPEDIA

Related topics and walkthroughs

CARDSAccuracy

Boosts Shiv damage and turns a small-hit package into serious offense.

CARDSAcrobatics

Draws several cards while discarding one, a tool for targeted deck cycling.

CARDSAdrenaline

Grants draw and energy without consuming normal energy; excellent for tempo.

CARDSAfter Image

Gains Block as cards are played, rewarding high-action turns.

CARDSBackflip

Offers Block and draws cards, enabling flexible defensive cycles.

CARDSBall Lightning

Attack that channels Lightning, adding damage and orb momentum.

CARDSBarricade

Keeps unspent Block between turns, supporting defensive scaling plans.

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Independent Volpedia editorial resource, not affiliated with Mega Crit. Original game (Slay the Spire 1), reviewed 2026-10-28. Slay the Spire 2 has separate rules, cards and characters and is not included here. Category graphics are original conceptual illustrations, not game screenshots or actual card artwork. Detailed numerical card costs, damage, upgrade effects and drop percentages are omitted where not individually checked. Editorial verification records are stored separately from public articles.