SLAY THE SPIRE / ENEMIES
Enemies
Common hallway threats and tactics by act.
10 entries · Reviewed 2026-10-28
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Enemies reference library
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10 of 10 entries · Original Slay the Spire 1
Enemies · REFERENCE
Jaw Worm
Early enemy whose attacks and buffs demand basic defensive sequencing.
Enemies · REFERENCE
Cultist
Early enemy that gains recurring Strength after setup.
Enemies · REFERENCE
Louse
Early enemy that can use Curl Up and varied intents.
Enemies · REFERENCE
Slaver
Act II enemy with dangerous attacks and disruptive debuffs.
Enemies · REFERENCE
Snake Plant
Act II enemy with repeated multi-hit attacks and defensive scaling.
Enemies · REFERENCE
Byrd
Act II flying enemy that can be grounded by repeated hits.
Enemies · REFERENCE
Chosen
Act II foe whose Hex debuff creates Dazed cards as you use Skills.
Enemies · REFERENCE
Snecko
Act II foe whose confusion effect changes card costs.
Enemies · REFERENCE
Spire Growth
Act III enemy that constricts the player until the debuff is removed.
Enemies · REFERENCE
Transient
Act III monster that disappears after a limited time, with huge attacks that weaken when damaged.
Independent Volpedia editorial resource, not affiliated with Mega Crit. Original game (Slay the Spire 1), reviewed 2026-10-28. Slay the Spire 2 has separate rules, cards and characters and is not included here. Category graphics are original conceptual illustrations, not game screenshots or actual card artwork. Detailed numerical card costs, damage, upgrade effects and drop percentages are omitted where not individually checked. Editorial verification records are stored separately from public articles.