What is Neutralize?
A cheap attack that applies Weak, enabling important damage prevention early.
This reference covers gameplay decisions in the original Slay the Spire. Character-specific options and relic synergy can change how useful an item is, so consider your current deck, health, upcoming enemy and available resources before applying a strategy.
When and how to use it
Use before other attacks when the intent indicates it lowers incoming damage.
What to avoid
Do not assume Weak affects non-attack enemy actions.