What is Strike?
Basic attack retained in the starting deck; it is usually weaker than later synergistic attacks.
This reference covers gameplay decisions in the original Slay the Spire. Character-specific options and relic synergy can change how useful an item is, so consider your current deck, health, upcoming enemy and available resources before applying a strategy.
When and how to use it
Remove surplus Strikes when doing so improves consistency and immediate defense.
What to avoid
Removing too many early attacks before Act 1 elites can leave a deck with no damage.