What is Neow?
Opening encounter offering a choice of run-start bonuses with differing costs.
This reference covers gameplay decisions in the original Slay the Spire. Character-specific options and relic synergy can change how useful an item is, so consider your current deck, health, upcoming enemy and available resources before applying a strategy.
When and how to use it
Evaluate the bonus against immediate Act I pathing and starter deck weaknesses.
What to avoid
Do not take maximum-HP loss blindly before a dangerous first elite.