SLAY THE SPIRE / PROGRESSION

Sapphire Key

A special key acquired from a chest in place of its relic.

QUICK REFERENCESlay the Spire 1Reviewed 2026-10-28Reference / noindex

OVERVIEW

What is Sapphire Key?

A special key acquired from a chest in place of its relic.

This reference covers gameplay decisions in the original Slay the Spire. Character-specific options and relic synergy can change how useful an item is, so consider your current deck, health, upcoming enemy and available resources before applying a strategy.

PRACTICAL STRATEGY

When and how to use it

Weigh the chest relic against the time remaining to collect the key.

COMMON MISTAKES

What to avoid

Missing every later chest can lock out Act IV.

CONTINUE ON VOLPEDIA

Related topics and walkthroughs

TIPSTrack three keys early

Act IV requires Ruby, Emerald and Sapphire Keys in one run.

MAPSTreasure Room

Chest offering a relic, or a Sapphire Key when available.

PROGRESSIONAct IV Unlock

Requires prior achievements with the core original characters before key collection becomes available.

PROGRESSIONAscension Ladder

Rising difficulty levels increase challenges one step after another.

PROGRESSIONCard Unlocks

Character progress awards additional cards and relics in later runs.

PROGRESSIONCharacter Unlocks

Progress opens additional original-game characters and their card/relic options.

PROGRESSIONCorrupt Heart Victory

Optional endgame objective for capable decks that collect the three keys.

Back to Progression

Independent Volpedia editorial resource, not affiliated with Mega Crit. Original game (Slay the Spire 1), reviewed 2026-10-28. Slay the Spire 2 has separate rules, cards and characters and is not included here. Category graphics are original conceptual illustrations, not game screenshots or actual card artwork. Detailed numerical card costs, damage, upgrade effects and drop percentages are omitted where not individually checked. Editorial verification records are stored separately from public articles.